Dicer相关论文
表观遗传学是指研究不改变DNA序列而基因表达发生可遗传改变的学科,非编码RNA是表观遗传学研究的重要内容之一,而micro RNA（miRNA）是......
研究背景及目的MICA/B是固有免疫系统的组成部分,在包括肝癌在内的多种肿瘤中高表达,通过与其受体NKG2D相互作用,发挥肿瘤免疫作用......
大脑皮层的有序发育对哺乳动物高级功能的建立至关重要,该过程受到严格的基因表达调控。因此探索大脑皮层发育过程中的分子调控机......
越来越多的证据表明,星形胶质细胞参与调节少突胶质细胞（oligodendrocyte,OL）形成髓鞘的过程,但其中有很多相关机制仍不清楚。功能性......
研究目的及背景:Dicer属于RNase Ⅲ核糖核酸内切酶家族,是microRNA加工过程的不可或缺的关键分子,对microRNA的功能发挥起重要作用......
Dicer是一种Ⅲ型核糖核酸内切酶,在RNA干扰(RNAi)途径中发挥重要作用.越来越多的证据表明,Dicer除产生小RNA外,还参与了染色质结构......
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Dicer蛋白属于RNaseⅢ家族成员,具有保守的结构域.miRNA是一类长度为22 nt左右的小RNA分子,mi-RNA的成熟是由Dicer蛋白剪切成熟的.......
The manner on the survival of genomic dsRNA of reoviruses from dsRNA-triggered and Dicer-initiated RNAi pathway remains ......
目的 Dicer 是核糖核酸酶Ⅲ家族的一员，是miRNA 成熟过程中必需的关键酶，而miRNA 与乳腺癌的发生发展以及耐药等方面密切相关.Dicer ......
Age-dependent neuron loss is associated with impaired adult neurogenesis in forebrain neuron-specifi
Impairment in the microRNA(miRNA)network causes a number of neurodegenerative diseases.Endoribonuclease Dicer is a key R......
Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurod
Minocycline is a broad-spectrum tetracycline antibiotic.A number of preclinical studies have shown that minocycline exhi......
Dicer play important roles in proliferation and invasion of HTR8 trphoblast cells and may modulate t
Ribonuclease Ⅲ Dicer is a rate-limiting enzyme in biogenesis of canonical microRNA,which is responsible for processing ......
Microglial DICER was phosphorylated at serine 1456 by c-jun N-terminal kinase(JNK)and downregulated in response to 1-met......
目的：探究卵巢癌细胞中Dicer低表达所引起的蛋白组学改变，并寻找Dicer下游关键靶蛋白，以明确Dicer调控卵巢癌细胞恶性生物学行为的分......
MicroRNA ablation affects Bergmann glial morphology and disrupts tissue morphogenesis in the develop
MicroRNAs (miRNAs) play important roles during development of the central nervous system (CNS).Several reports indicate ......
RNA干扰(RNA interference,RANi)是由双链RNA (double-stranded RNA,dsRNA)引发,使得mRNA降解或翻译被抑制的现象,在真核生物中高......
MicroRNA(miRNA)-related single nucleotide polymorphisms (miR-SNPs) in miRNA processing machinery genes in cancer patient......
目的 观察Dicer基因在甲状腺乳头状癌(PTC)中的表达,探讨Dicer基因表达与PTC的发生发展的关系.方法 采用免疫组织化学链菌素抗生物......
目的 探讨PIWIL1蛋白与DICER酶在肝细胞癌组织中的表达及临床意义.方法 免疫组化检测47例肝细胞癌标本中PIWIL1与DICER的表达.蛋白......
RNAi(RNA interference)现象的发现及其在生物学上的应用无疑具有划时代的意义.其快速、简洁、特异性强的优点,使其一出现就受到科......
Genome-wide characterization and expression profiling of the RNAi pathway genes in the diamondback m
Although RNAi (RNA interference) has been widely used for genetic research in insects, the detailed mechanism is not......
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Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell act
AIM:To investigate the continuous hepatic histopathological processes which occur in response to the loss of Dicer1.METH......
microRNAs(miRNAs)是一类长约23个核苷酸的非编码小RNA,通过其诱导的沉默复合物(miRNA-induced silencing complex,miRISC)在转录......
Dicer和Ago2是RNA干扰(RNAi)中重要的酶,本研究检测常见自身免疫病系统性红斑狼疮(SLE)、类风湿关节炎(RA)和强直性脊柱炎(AS)患者......
自 1 971年Folkman首先提出肿瘤生长具有血管依赖性假设以来 ,抑制肿瘤血管新生作为肿瘤治疗的一个途径日益受到重视。肿瘤血管新......
The means of survival of genomic dsRNA of reoviruses from dsRNA-triggered and Dicer-initiated RNAi pathway remains to be......
Dicer酶是RNaseⅢ家族成员,是miRNA成熟的关键酶,Dicer表达水平直接影响着miRNA的表达及其靶基因的调控能力,进而调节生物体的生命......
A large number of proteins involved in RNA metabolism possess a double-stranded RNA-binding domain (dsRBD),whose sequenc......
目的:Dicer是核糖核酸酶III家族的一员,是miRNA成熟过程中必需的关键酶,而miRNA与乳腺癌的发生发展以及耐药等方面密切相关。Dicer......
MicroRNAs(miRNAs)是一类16-29nt长的分布极其广泛的小的非编码RNAs,作为RNA干扰沉默复合体的一部分,其最主要的作用是特异性靶向......
研究目的和背景前期我们课题组发现,SATTB2上调后的结直肠癌细胞其增殖、运动侵袭能力明显受抑;microRNA芯片检测的结果表明,上调......
MicroRNAs (miRNAs) are small non-coding RNAs that are important in regulating metabolic stress. In this study, we determ......
MicroRNAs play important roles in post-transcriptional regulation of gene expression by inhibiting protein translation a......
微RNA(miRNA)是一类非编码单链小分子RNA,在转录后水平调节基因的表达。最新研究发现miRNA与人类肿瘤密切相关,甚至有人认为某些mi......
目的:微小RNA(microRNAs,miRNAs)在胆固醇的合成,代谢和转运中起着重要作用,而mi RNAs在胆固醇代谢物胆酸的代谢和转运中的作用尚......
Can we treat neurodegenerative diseases by preventing an age-related decline in microRNA expression?
MicroRNA pathway is down-regulated in aged dopaminergic neurons:Parkinson’s disease(PD)is the most frequent motor neuro......
目的:研究前列腺特异转录因子NKX3.1对Dicer1基因表达的影响。方法:转染pcDNA3.1-NKX3.1至前列腺癌PC3细胞,通过G418筛选,有限稀释......
目的:探究Dicer在胃癌中的表达情况、与临床病理参数的相关性及对细胞生长和迁移的作用。方法:收集56例胃癌患者的癌组织样本和癌......
RNAi(RNAinterference)现象的发现及其在生物学上的应用无疑具有划时代的意义。其快速、简洁、特异性强的优点,使其一出现就受到科......
Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides (nt) in length that play importan......
The discovery of microRNAs (miRNAs) is a remarkable breakthrough in the field of molecular genetics, as miRNAs are key a......
